Advanced Search Abstract Objective. This systematic review examines the diagnostic value of the digital rectal examination DRE for the diagnosis of prostate cancer. Only studies relating to unselected populations and using either biopsy or surgery as the reference standard were included.
His essentially affirmative vision and lyrical style are not merely and superficially willed; rather, they are earned. It evokes a nearly liturgical dimension that leads the reader to believe, as Cheever did, that the purpose of both writing and living is to enlarge humankind rather than to diminish it.
Because his vision is earned rather than willed, the fiction operates not at the extreme of faith but between the poles which Cheever variously described: They suffer, often seriocomically, from loneliness and from a loss of self-esteem; often but by no means always they live well if precariously financially, but they are generally bereft emotionally and spiritually impoverished.
At a time of considerable literary experimentation, Cheever found himself either praised or damned as a conservative in terms of both values and style—this despite the fact that his achievement derives in large measure from his having so successfully managed either to transcend or to undermine the very formulas used to pigeonhole his work.
The Wapshot Chronicle First published: Novel In this family chronicle, the youngest generation of Wapshots encounters the waywardness of love and of contemporary life.
The pace changes and the continuity dissolves as the novel moves through three progressively Chetner essay parts of seventeen, then ten, and finally five chapters, to end back in St.
Botolphs on yet another Fourth of July a few years later. It adds an element of ceremony but also of arbitrariness that corresponds to the relation between St.
Botolphs and the world outside its borders, where much of the novel takes place. The relation between these worlds and between tradition and independence itself an American traditionbetween a past which both sustains and confines and a present which frees but also dismays and displaces forms the thematic center of a novel that is about the need to bridge the two worlds and all they represent.
Once the brothers leave St. Moses goes to Washington, gets a government job that is so secret that the narrator cannot discuss it, has an affair with a married woman named Beatrice, gets fired, leaves Washington, goes fishing, comes to the aid of a wealthy man whose gratitude includes hiring Moses, and falls in love with and marries Melissa, the ward of a distant cousin, Justina Wapshot Molesworth Scaddon.
Both couples reunite, and both Moses and Coverly father sons and so fulfill the terms Honora set for establishing trusts in their names, part of which the brothers will use to buy Leander a new boat.
Novel The comic waywardness of The Wapshot Chronicle gives way to the confusions and discontinuities of the contemporary world. Similarities between The Wapshot Scandal and the work to which it serves as sequel, The Wapshot Chronicle, are readily apparent: Botolphsand the interweaving of multiple narratives.
Honora, still eccentric but now more sympathetic, tries to escape persecution for nonpayment of taxes by traveling to Italy. There she finds herself homesick rather than free and, in the company of an equally lonely Internal Revenue Service agent, returns to St.
Botolphs, where she must forfeit the family fortune and soon drinks herself to death a death that Cheever somehow seems to make funny. Cheever depicts the lives of Coverly and Betsey in a missile-site housing complex named Talifer and of Moses and Melissa in affluent Proxmire Manor.
The differences between the two books, however, are of greater importance than the similarities. The temporal vagaries of The Wapshot Chronicle here seem more pronounced, resulting in a more mythified realism, a fictive world that is simultaneously now and never.
It is at once more intimate and more detached.
He claims to have personal knowledge of the Wapshots, who, he says, always made him feel like an outsider.Jul 24, · Multiple sclerosis (MS) is a chronic, progressive central neurological disease characterized by inflammation and demyelination.
In patients with MS, dysregulation of the autonomic nervous system may present with various clinical symptoms including sweating abnormalities, urinary dysfunction, orthostatic dysregulation, gastrointestinal symptoms, and sexual dysfunction. Described herein are methods and kits for prognosis of prostate cancer in a subject.
The methods comprises: (a) determining the ratio of PCA3 and PSA expression in a urine sample and (b) correlating the value of the PCA3/PSA ratio with the aggressiveness and mortality risk of prostate cancer in the subject. Kits for prognosing prostate cancer are also described.
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Calgary, the Chetner’s generously offer over $ in cash prizes every year. Entrants from across Canada are welcomed to submit an essay if they are a Canadian, post-secondary student.
Abstract. We demonstrate that the androgen receptor (AR) regulates a transcriptional program of DNA repair genes that promotes prostate cancer radioresistance, providing a potential mechanism by which androgen deprivation therapy synergizes with ionizing radiation.
Dr. Timothy Boone is an urologist in Houston, Texas and is affiliated with Houston Methodist Hospital. He received his medical degree from University of Texas Medical School and has been in.